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1,2 Even with a 12-fold increase of oral vitamin C from 200 mg/day to 2500 mg/day the plasma concentration of vitamin C only increases by 25% from 1.2 to 1.5 mg/dL and with further increased dosing only to 9.3 mg/ dL 1,2 .Similarly, oral supplementation with magnesium results in little or no change in serum magnesium concentrations, whereas IV administration can double or triple the serum levels at least for a short period of time