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Laboratory Tests During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary

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Initially 250 to 1000 micrograms intramuscularly on alternate days for one or two weeks, then 250 micrograms weekly until the blood count is normal Maintenance: 1000 micrograms every two to three months Addisonian pernicious anaemia and other macrocytic anaemias with neurological involvement Initially:1000 micrograms on alternate days as long as improvement is occurring