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membrane phospholipids are hydrolyzed to lysophospholipids by PLA2, then converted to LPA by autotaxin (ATX), the key enzyme encoded by ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) ( Figure 1 2.2 The LPA-LPAR signaling pathway LPA’s diverse biological functions have earned it the designation “multifunctional phosphate messenger.” Since the first LPA receptor identification and cloning in 1996 ( Table 1 )

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