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GSH reduces the oxidized catalytic cysteine (Cys47-SOH) of PRDX6, sustaining its peroxidase activity against lipid peroxides, like GPX4, and linking PRDX6 directly to ferroptosis resistance (Fig
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Neuronal cells were seeded at 2.5 × 10 4 cells per well in 96-well plates, and 25 μM of H 2 DCFDA was added prior to Tat and/or MSM administration and incubated for 45 min
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