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81 PEGylation, which is widely employed to prolong liposomal circulation time, can induce undesirable immune responses, particularly the formation of anti-PEG antibodies (IgM/IgG), leading to accelerated blood clearance (ABC) of liposomes

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6 Challenges and prospects 6.1 The complex interaction between bioavailability, metabolism, and intestinal pathology The clinical application of polyphenols is severely limited by their inherent characteristics, including chemical instability, low absorption rate in the gastrointestinal tract, and extensive and rapid metabolism by host enzymes and gut microbiota, resulting in generally low bioavailability of most polyphenols and significant individual differences