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However, some studies have shown that excessive ferroptosis can lead to the release of damage-associated molecular patterns and the activation of immune responses triggered by ferroptotic damage, which promote tumor growth and metastasis

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Malate in plants is involved in photosynthesis (C3, C4, and CAM plants), respiration and energy metabolism, fatty acid oxidation, stomatal, and pulvinual movement, lignin biosynthesis, nitrogen fixation, amino acid biosynthesis, ion balance, P- and Fe-uptake, and Al-tolerance (reviewed by Finkemeier and Sweetlove, Metal(loid)-specificity and -chelation mechanisms Metal-complexation with OAs has been argued to have potential role in the long distance xylem transport of heavy metals (Rascio and Navari-Izzo, 2011)

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