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PMID: 12136066 www.rxlist.com (Lamictal ®) Keywords Levetiracetam Trade Name: Keppra ® Drug Class: Broad spectrum antiepileptic Mechanism of Action: evidence suggests that it reduces neurotransmitter release by: binding to synaptic vesicular protein SV2A, inhibiting vesicle fusion (Lynch et al 2004) inhibiting presynaptic calcium channels (Vogi et al, 2012) Indications: partial onset seizures myoclonic seizures in patients with juvenile myoclonic epilepsy primary generalized tonic-clonic seizures Side Effects: behavioral abnormalities aggression, agitation, anger, anxiety, apathy, depersonalization, depression, hostility, hyperkinesias, neurosis, personality disorder psychotic symptoms suicidal behavior and ideation coordination difficulties somnolence, fatigue Stevens-Johnson syndrome hematologic abnormalities (decreased WBC counts), decreased hemoglobin/hematocrit Pharmacokinetics: available in different formulations, including oral, extended-release oral, and suspensions for iv injection Figure 1