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Indeed, a series of studies, using in vivo brain imaging in both animal models and humans, has documented, in the course of depression, an increase in key brain areas of a marker of inflammatory activation of microglia

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NAC may be useful when: Cysteine availability may be limiting The goal is to support internal glutathione synthesis Direct glutathione is poorly tolerated A clinician has identified a relevant medical or nutritional reason NAC does not guarantee that glutathione production will increase adequately