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Preclinical research suggests that NNMT inhibition may: Influence fat-cell metabolism Reduce fat accumulation Increase energy expenditure Support healthier metabolic signalling Improve glucose handling in animal models Influence NAD+ and cellular energy pathways Potentially improve body composition without relying primarily on appetite suppression In diet-induced obese mice, NNMT inhibition has been associated with reductions in body weight and fat mass, alongside metabolic improvements

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However, increasing oral supplement doses (within safe limits) while awaiting medical review is generally considered safe, as B12 has very low toxicity and excess is excreted through the kidneys