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The correction of potassium and/or calcium deficits may be difficult to achieve unless the magnesium deficit is also corrected, hence in patients with hypokalemia and/or hypocalcemia, a magnesium deficiency should be considered [220]

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Copper peptides are generally safe for most people when used topically, as they don't enter the body to produce systemic effects, but copper peptides might not be appropriate for people with a known allergy or sensitivity to copper