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The polarity of MMF also influences its other properties—for example, the affinity of carboxylesterases (CESs), whose structural conformation is generally more suitable for binding non-polar (hydrophobic) molecules such as DMF [23,59]

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63 One well-known finding is that HDAC2 expression/activity is reduced in peripheral blood and alveolar macrophages of severe asthmatics, especially those with corticosteroid resistance